IN VITRO AND XENOGRAFT ANTI-TUMOR ACTIVITY OF A HALOGENATED-XANTHENE AGAINST REFRACTORY PEDIATRIC SOLID TUMORS

• Main Authors: SWIFT LUCY, ZHANG CHONGHUI, TRIPPETT TANYA, NARENDRAN ARU, SINGH JASKARAN, WACHTER ERIC A
• Format: Patent
• Language: Chinese; English
• Published: 18.06.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A method of treating a pediatric cancerous solid tumor in a mammalian subject is disclosed that comprises intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor. Another contemplated method comprises the steps of intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor and systemically administering a tumor-inhibiting effective amount of a systemic anti-cancer medication that provides synergistic cytotoxicity with the halogenated xanthene. The two administrations can occur concurrently, or one prior to the other. 本发明公开了一种在哺乳动物受试者中治疗小儿癌性实体瘤的方法，该方法包括病灶内施用一定量的引起所施用肿瘤的肿瘤细胞消融的卤代呫吨或其药学上可接受的盐，优选玫瑰红二钠。另一种涉及的方法包括以下步骤：病灶内施用一定量的引起所施用肿瘤的肿瘤细胞消融的卤代呫吨或其药学上可接受的盐，优选玫瑰红二钠，和全身性施用肿瘤抑制有效量的全身性抗癌药物，其与卤代呫吨一起提供协同细胞毒性。两种施用可以同时进行，或可以先后