Novel antagonistic anti TNFR2 antibody molecules

• Main Authors: HOLMKVIST PETRA, SEMMRICH MONIKA, FRENDEUS BJORN, MARTENSSON LINDA, TEIGE INGRID
• Format: Patent
• Language: Chinese; English
• Published: 11.06.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Described are novel antagonistic antibody molecules that specifically bind to TNFR2 on a target cell and thereby block TNF-[alpha] binding to TNFR2 and block TNFR2 signaling, wherein the antibody molecules also bind to Fc receptors via the Fc region. Also described is the use of such antibody molecules in treatment of cancer or infections caused by intracellular pathogens. 描述了新型拮抗性抗体分子，所述新型拮抗性抗体分子与靶细胞上的TNFR2特异性结合并且由此阻断TNF-α与TNFR2的结合并且阻断TNFR2信号传导，其中所述抗体分子还通过其Fc区与Fc受体结合。还描述了此类抗体分子在治疗癌症或由细胞内病原体引起的感染中的用途。