METHOD OF TREATMENT OF NEUROENDOCRINE TUMORS

• Main Authors: BRAMBATI CLEMENTINA, BUONO STEFANO, BARBATO DONATO, LOPERA-SIERRA MARIBEL, MARIANI MAURIZIO, DE PALO FRANCESCO, FUGAZZA LORENZA, CHICCO DANIELA, TESORIERE GIOVANNI
• Format: Patent
• Language: Chinese; English
• Published: 11.06.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to methods of treating cancers that over-express somatostatin receptors, e.g. neuroendocrine tumors (NET). In particular, the invention provides novel therapies based on the combination of a peptide receptor radionuclide therapeutic (PRRT) agent and immuno-oncology (I-O) therapeutic agents, wherein said I-O therapeutic agents are selected from the group consisting of LAG-3 inhibitors, TIM-3 inhibitors, GITR angonists, TGF-beta inhibitors, IL15/IL-15RA complex, and selected PD-1 inhibitors. 本发明涉及治疗过表达生长抑素受体的癌症、例如神经内分泌肿瘤(NET)的方法。具体而言，本发明提供了基于肽受体放射性核素治疗剂(PRRT)和免疫肿瘤学(I-O)治疗剂的组合的新型疗法，其中所述I-O治疗剂选自由以下组成的组：LAG-3抑制剂、TIM-3抑制剂、GITR激动剂、TGF-β抑制剂、IL15/IL-15RA复合物、和选择的PD-1抑制剂。