Macrolactam compound FW05328-d and efficient fermentation method thereof

• Main Authors: JIANG HONG, SUN FEI, FANG ZHIKAI, ZHAO WEI, CHEN LI, ZHOU JIAN
• Format: Patent
• Language: Chinese; English
• Published: 11.06.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PROCESSES USING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention belongs to the technical field of microbial fermentation, particularly relates to a structural analogue FW05328-d of a macrolactam compound FW05328-1, and further discloses an efficient fermentation method of the structural analogue by utilizing amino acid induction. The macrolactam compound FW05328-d is the structural analogue of the developed macrocyclic lactam compound FW05328-1, the structure of the compound FW05328-d is one -OH less than that of the compound FW05328-1 on the tenth site, the substance structure and chemical performance of the compound FW05328-d are more stable, and the macrolactam compound FW05328-d is more suitable for large-scale production. The antitumor activity test of the macrolactam compound FW05328-d proves that the compound has the activity of resisting mouse melanoma cell strains, human esophageal cancer cell strains and human colon cancer cell strains, and has better medical value. 本发明属于微生物发酵技术领域，具体涉及一种大环内酰胺化合物FW05328-1的结构类似物FW05328-d，并进一步公开一种利用氨基酸诱导高效发酵该结构类似物的方法。