TCA CYCLE INTERMEDIATES AND METHOD OF USE THEREOF

• Main Authors: LEVIN ANDREW D, PATEL JIGAR, GROS DAVID-ALEXANDRE
• Format: Patent
• Language: Chinese; English
• Published: 01.06.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention generally relates to non-oral formulations of TCA cycle intermediates and methods of using such formulations for treating metabolic disorders. In certain embodiments, the invention provides therapeutic compositions containing succinate formulated for non-oral administration and methods of using such compositions to treat metabolic disorders. The invention also provides combination therapies that include compositions containing succinate formulated for non-oral administration and compositions containing citrate (optionally formulated for oral administration) and methods of using such combination therapies to treat metabolic disorders. 本发明总体上涉及TCA循环中间体的非口服制剂和使用这种制剂治疗代谢障碍的方法。在某些实施例中，本发明提供了被配制成用于非口服施用的含有琥珀酸盐的治疗组合物，和使用这种组合物治疗代谢障碍的方法。本发明还提供了联合疗法，其包括被配制成用于非口服施用的含有琥珀酸盐的组合物和含有柠檬酸盐的组合物(任选地被配制成用于口服施用)，和使用这种联合疗法治疗代谢障碍的方法。