Freeze drying method of azithromycin for injection

The invention provides a freeze-drying method of azithromycin for injection, which comprises the following steps: (1) mixing azithromycin with a citric acid solution and a citric acid-sodium hydroxide mixed solution in sequence, stirring for clarification, and adjusting the pH value to obtain an azi...

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Bibliographic Details
Main Authors LIU JINGPING, JI ZIZHEN, LIU QUANGUO, MAI FAREN, WU WEIZHEN, HAN YUYAN, CHEN KELING, CHEN YUZHU, WU YUHAN
Format Patent
LanguageChinese
English
Published 01.06.2021
Subjects
BLASTING
DRYING
DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
HEATING
HUMAN NECESSITIES
HYGIENE
LIGHTING
MECHANICAL ENGINEERING
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
WEAPONS
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Summary:The invention provides a freeze-drying method of azithromycin for injection, which comprises the following steps: (1) mixing azithromycin with a citric acid solution and a citric acid-sodium hydroxide mixed solution in sequence, stirring for clarification, and adjusting the pH value to obtain an azithromycin solution before freeze-drying; (2) after low-temperature water is sprayed outside the filled liquid medicine, pre-freezing; (3) heating the temperature to -10 DEG C from -45 DEG C within 110-130 min at the vacuum degree of 18-22 Pa, keeping the temperature, increasing the vacuum degree to 28-30 Pa, keeping the temperature, recovering the vacuum degree to 20-25 Pa, and continously keeping the temperature; gradually raising the temperature from -10 DEG C to 0 DEG C within 50-70 minutes, and keeping the temperature; and (4) analyzing and drying to obtain the azithromycin freeze-dried powder injection for injection. According to the method, the high-stability azithromycin solution before freeze-drying is comb
Bibliography:Application Number: CN202011633287