Sclerotiorin solid dispersion and preparation method and application thereof

• Main Authors: CHEN DONGNI, LU YONGJUN, SHE ZHIGANG
• Format: Patent
• Language: Chinese; English
• Published: 01.06.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a Sclerotiorin solid dispersion and a preparation method and application thereof. The Sclerotiorin solid dispersion comprises Sclerotiorin and PVP-k30 which are mixed in proportion, and the mass ratio of the Sclerotiorin to the PVP-k30 can be 1: 4, 1: 6 or 1: 8. The Sclerotiorin solid dispersion has the following beneficial effects: due to poor water solubility and poor oral absorption of the existing Sclerotiorin, the application of the Sclerotiorin in the field of medicine is limited, and the difficult points of poor water solubility and poor oral absorption of the Sclerotiorin are firstly solved; and experiments prove that the obvious highest peak of blood concentration can be detected after a rat orally takes the medicine for 4 hours, but the blood concentration peak cannot be detected when the raw material Sclerotiorin is orally taken, so that a foundation is laid for creating a novel high-efficiency and low-toxicity anti-tuberculosis medicine. 本发明公开了一种核丛青霉素固体分散体、制备方法及其应用，包括按照比例混合