Triterpene saponin analogues

• Main Authors: LIVINGSTON PHILIP, GARDNER JEFFREY, MARTIN J. TYLER, NORDSTROEM LARS, CHEA ERIC, FERNANDEZ-TEJADA ALBERTO, GIN DAVID Y, LEWIS JASON, RAGUPATHI GOVIND, TAN DEREK, PILLARSETTY NAGA VARA KISHORE
• Format: Patent
• Language: Chinese; English
• Published: 18.05.2021
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases. 本申请涉及三萜糖苷皂苷衍生的佐剂，其合成及其中间体。本申请还提供了包含本发明化合物的药物组合物以及使用所述化合物或组合物治疗和免疫感染性疾病的方法。