COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING AMYLIN, AN AMYLIN RECEPTOR AGONIST OR AN AMYLIN ANALOG, AT LEAST ONE IONIC SPECIES AND AN AMPHIPHILIC COMPOUND CONTAINING HYDROPHOBIC RADICALS

• Main Author: DAUTY EMMANUEL
• Format: Patent
• Language: Chinese; English
• Published: 14.05.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a composition in the form of an injectable solution, the composition comprising: amylin, an amylin receptor agonist or an amylin analog; at least one ionic species; and an amphiphilic compound comprising a hydrophilic skeleton HB, substituted by at least one hydrophobic radical -Hy of formula (I). The invention further relates to a composition according to the invention, characterised in that it also comprises prandial insulin. In one embodiment, the composition also comprises GLP-1, GLP-1 analogs, and GLP-1 receptor agonists, commonly called GLP-1 RA. 本发明涉及可注射溶液形式的组合物，其包含：胰淀素、胰淀素受体激动剂或胰淀素类似物；至少一种离子物质；以及两亲化合物，其包含被至少一个式(I)疏水基团-Hy取代的亲水骨架HB。本发明还涉及根据本发明的组合物，特征在于，其还包含餐时胰岛素。在一个实施方案中，所述组合物还包含GLP-1、GLP-1类似物和通常称为GLP-1RA的GLP-1受体激动剂。