METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS

• Main Author: ROTHBAUM WAYNE
• Format: Patent
• Language: Chinese; English
• Published: 14.05.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Therapeutic methods and pharmaceutical compositions for treating a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis, are described. In certain embodiments, the invention includes therapeutic methods of treating a MPN using a combination of a compound of Formula (I) or Formula (II) with a therapeutic agent selected from the group consisting of a JAK inhibitor, an IDH inhibitor, a PD-1 inhibitor, a PD-L1 inhibitor, a PD-L2 inhibitor, an interferon, a PI3K inhibitor, an AKT inhibitor, an mTOR inhibitor, a nucleoside analog, and combinations thereof. 描述了用于治疗骨髓增殖性肿瘤(MPN)，包括真性红细胞增多症(PV)、特发性血小板增多症(ET)和骨髓纤维化的治疗方法和药物组合物。在某些实施例中，本发明包括使用式(I)或式(II)的化合物与治疗剂的组合治疗MPN的治疗方法，所述治疗剂选自由JAK抑制剂、IDH抑制剂、PD-1抑制剂、PD-L1抑制剂、PD-L2抑制剂、干扰素、PI3K抑制剂、AKT抑制剂、mTOR抑制剂、核苷类似物及其组合组成的群组。