Preparation method of PEG/PEI-modified magnetic nanoparticles

• Main Authors: LIU YAN, DA XIANHONG, GU FENFEN, LU YUNSHU, LI XIANG, LI RUONAN
• Format: Patent
• Language: Chinese; English
• Published: 14.05.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention provides a preparation method of magnetic nanoparticles. The preparation method is characterized by comprising the following steps: S1, adding alcohol into vortex iron particles, and dispersing the vortex iron particles via ultrasonic treatment; S2, carrying out magnetic adsorption separation to remove alcohol; S3, adding PEG and/or PEI and water, and performing ultrasonic emulsification; and S4, discarding a supernatant, conducting washing with water and alcohol respectively, collecting a precipitate, and drying the precipitate to obtain the PEG and/or PEI modified magnetic nanoparticles. The obtained nano-carrier is low in toxicity and good in effect. 本发明提供了一种磁性纳米颗粒的制备方法，其特征在于，由如下步骤制备而成:S1.向涡旋铁颗粒中加入醇后，超声使其分散；S2.经磁吸附分离，去除醇；S3.添加PEG和/或PEI、水后，超声乳化；S4.弃上清液后，用水和醇分别洗涤，收集沉淀干燥后即得到PEG和/或PEI修饰的磁性纳米颗粒。该纳米载体毒性低，效果好。