DIAGNOSIS OF DEMENTIA BY VASCULAR MAGNETIC RESONANCE IMAGING

A method of diagnosing a likelihood of onset or progression of Alzheimer's disease and related dementias (ADRD) in a subject is provided. The method requires determining vascularization changes in different regions of the brain on the basis of a quantitative cerebral blood volume (qCBV) map of...

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Bibliographic Details
Main Authors GHARAGOUZLOO CODI AMIR, FERRIS CRAIG
Format Patent
LanguageChinese
English
Published 11.05.2021
Subjects
DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MEDICAL OR VETERINARY SCIENCE
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SURGERY
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Summary:A method of diagnosing a likelihood of onset or progression of Alzheimer's disease and related dementias (ADRD) in a subject is provided. The method requires determining vascularization changes in different regions of the brain on the basis of a quantitative cerebral blood volume (qCBV) map of the subject's brain. The qCBV is obtained from one or more quantitative ultrashort time-to-echo contrast-enhanced (QUTE-CE) MRI images of the brain. A method of treating a subject for ADRD is provided. Diagnostic markers for onset and progression of Alzheimer's disease are also provided. 提供了一种诊断受试者的阿尔茨海默病和相关痴呆(ADRD病)发作或进展的可能性的方法。该方法要求根据受试者大脑的定量脑血容量(qCBV)图确定大脑不同区域的血管化变化。qCBV是从一幅或多幅脑部定量超短回波时间对比增强(QUTE-CE)MRI图像中获得的。提供了一种治疗ADRD病患者的方法。还提供了阿尔茨海默病发作和进展的诊断标志物。
Bibliography:Application Number: CN201980064257