SINGLE MOLECULE SEQUENCING PEPTIDES BOUND TO THE MAJOR HISTOCOMPATIBILITY COMPLEX

The present disclosure provides methods of identifying and quantifying the peptides displayed by the major histocompatibility complex (MHC). Such methods may comprise the ability to determine the type, identity, and quantity of each peptide displayed by the MHC. In some embodiments, these methods ma...

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Bibliographic Details
Main Authors WANG SIYUAN STELLA, BARDO ANGELA M, SWAMINATHAN JAGANNATH, TU FUQUAN, MARCOTTE EDWARD, BOULGAKOV ALEXANDER, ANSLYN ERIC
Format Patent
LanguageChinese
English
Published 30.04.2021
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
SUGARS
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Summary:The present disclosure provides methods of identifying and quantifying the peptides displayed by the major histocompatibility complex (MHC). Such methods may comprise the ability to determine the type, identity, and quantity of each peptide displayed by the MHC. In some embodiments, these methods may be used to develop an anti-cancer therapy or type the HLA of a patient. Also provided herein are compositions comprising peptides from the MHC which have been prepared for sequencing. 本公开提供鉴定并定量由主要组织相容性复合体(MHC)展示的肽的方法。此类方法可包括确定每种由MHC展示的肽的类型、识别信息和数量的能力。在一些实施例中，这些方法可用于发展抗癌疗法或测定患者HLA的类型。本文还提供包含来自所述MHC的肽的组合物，所述肽已经过制备以进行测序。
Bibliography:Application Number: CN201980059281