Application of ellagic acid in preparation of medicine for relieving eye tissue lesions

• Main Authors: ZHANG YANZHI, ZHU YINGLING, ZHANG YAN, GULIMILA, GULIHAIXIA, JIA'NAER YIBULAAHONG, WANG QING, HUANG QIMIN, LI QIAN
• Format: Patent
• Language: Chinese; English
• Published: 30.04.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of treatment of ocular tissue lesions, and particularly discloses application of ellagic acid in preparation of a medicine for relieving ocular tissue lesions, wherein the ellagic acid can regulate and control the rise of the expression level of LC3b/a protein and the reduction of the expression level of p62 protein in eyeball tissues of diabetic mice, improve autophagy disorder of diabetic ocular tissues, relieve diabetic mouse eye tissue pathological injury, inhibit eye tissue inflammation NLRP3 and IL-1beta protein expression, inhibit eye tissue apoptosis protein c-caspase1 expression, and inhibit mouse eye tissue pyroptosis protein GSDME, GSDME-N and GSDMD-N expression, so that GSDMD and GSDME mediated pyroptosis is inhibited, and an anti-inflammatory protection effect on cells is achieved. The ellagic acid provided by the invention can relieve pathological injury of eye tissues of diabetic mice and has a protective effect on retinas of the diabetic mice. 本发明涉及