Near-infrared-ray-controlled nano-gas diagnosis and treatment agent, preparation method therefor and application of near-infrared-ray-controlled nano-gas diagnosis and treatment agent

• Main Authors: JIN ZHAOKUI, DUO YANHONG, WEN YANYUAN, ZHAO PENGHE, HE QIANJUN
• Format: Patent
• Language: Chinese; English
• Published: 13.04.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a near-infrared-ray-controlled nano-gas diagnosis and treatment agent, a preparation method therefor and application of the near-infrared-ray-controlled nano-gas diagnosis and treatment agent. The near-infrared-ray-controlled nano-gas diagnosis and treatment agent comprises two-dimensional nanosheets and loads loaded to the two-dimensional nanosheets, wherein the loads comprise a transition-metal carbonyl compound or nucleophilic NO donor. The near-infrared-ray-controlled nano-gas diagnosis and treatment agent is simple in preparation method, releases CO or NO gas in response to near-infrared rays and can be used for achieving ingenious combination between low-toxicity efficient tumor optothermal therapy and gas treatment, the treatment efficiency is increased greatly, and thus, development of clinical applications is facilitated. 本发明提供一种近红光控纳米气体诊疗剂及其制备方法和应用，其中，近红光控纳米气体诊疗剂包括二维纳米片以及装载在所述二维纳米片上负载物，所述负载物包括过渡金属羰基化合物或亲核NO供体，所述近红光控纳米气体诊疗剂制备方法简单，在近红外光响应下释放CO或NO气体，能够实现低毒高效的肿瘤光热疗法与气体治疗巧妙联合，大大提高了