Synthesis method of remdesivir intermediate triazinamine derivative

• Main Authors: ZHUANG JIANG, YU JURONG
• Format: Patent
• Language: Chinese; English
• Published: 09.04.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a synthesis method of a remdesivir intermediate triazinamine derivative. The remdesivir intermediate triazinamine derivative is prepared by adopting a unique synthesis method. The invention solves the problems of expensive raw materials, large amount of wastewater in the production process and the like in existing reaction of a remdesivir intermediate triazinamine derivative, and provides the novel synthesis method of the remdesivir intermediate triazinamine derivative, wherein the synthesis method has the advantages of simple preparation method, cheap and easily available raw materials, greatly reduced production cost, less wastewater and the like; the synthesis method is never reported in the prior art, is a brand-new preparation method of the remdesivir intermediate triazinamine derivative, and provides a new synthesis idea for similar compounds of remdesivir. 本发明公开了一种瑞德西韦中间体三嗪胺衍生物的合成方法，采用了独特的合成方法来进行制备。本发明解决了现有瑞德西韦中间体三嗪胺衍生物的反应中原材料较贵，生产过程中废水大等问题，提供了一种新的瑞德西韦中间体三嗪胺衍生物的合成方法，具有制备方法简单，原材料