Everolimus-containing composition and preparation method thereof

• Main Authors: ZHANG XIANTAO, HE SHENGJIANG, TANG WENXING, TAN BIN, SU HUANPENG
• Format: Patent
• Language: Chinese; English
• Published: 09.04.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a preparation method of an everolimus-containing composition, which comprises the following steps of: mixing everolimus, an antioxidant, hydroxypropyl methylcellulose and an organic solvent to obtain a first mixture; mixing the first mixture with lactose to obtain a second mixture; and carrying out dynamic vacuum drying on the second mixture, the dynamic vacuum drying being that a third mixture is subjected to vacuum drying in a non-static state, wherein in parts by mass, the composition sequentially and respectively comprises 1 to 5 parts of everolimus, 0.01 to 0.05 part of the antioxidant, 5 to 15 parts of hydroxypropyl methylcellulose and 1 to 5 parts of lactose. 本发明公开了一种含依维莫司的组合物的制备方法，包括以下步骤：将依维莫司、抗氧剂、羟丙甲纤维素及有机溶剂混合，得到第一混合物；将所述第一混合物与乳糖混合得到第二混合物；对所述第二混合物进行动态真空干燥，所述动态真空干燥为使得所述第三混合物在非静止状态下进行真空干燥；其中，所述依维莫司、所述抗氧剂、所述羟丙甲纤维素、所述乳糖的质量份数依次分别为1～5份、0.01～0.05份、5～15份、1～5份。