Oxaprozin enteric-coated pellet, medicament and preparation method thereof

• Main Authors: TANG JINRONG, LIAN XINJIE, ZHANG BO, LUO DAN, LUO HONG, YAN DONG, GUO MIN, HU JING, JIANG MIN
• Format: Patent
• Language: Chinese; English
• Published: 06.04.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an oxaprozin enteric-coated pellet, which comprises oxaprozin, an excipient, an adhesive and a coating material, and the mass ratio of oxaprozin to the excipient to the adhesive to the coating material is 1: (0.3-1): (0.05-0.2): (0.08-0.2). In addition, the invention also discloses a preparation method of the oxaprozin enteric-coated medicament, the pellet and the medicament. The product is stable in gastric juice and good in dissolution rate in intestinal tracts; the damage of gastric juice to oxaprozin is avoided, so that the stability of oxaprozin is guaranteed, the contact area is increased, and the bioavailability is further improved. 本发明公开了一种奥沙普秦肠溶微丸，包括奥沙普秦、赋形剂、粘合剂和包衣材料，奥沙普秦、赋形剂、粘合剂和包衣材料质量比为1:(0.3～1):(0.05～0.2):(0.08～0.2)；另外，本发明还公开了一种奥沙普秦肠溶药剂，及微丸和药剂的制备方法。本发明在胃液中稳定而在肠道中溶出度良好；避免了胃液对奥沙普秦的破坏，从而保证了奥沙普秦的稳定性，增加了接触面积，进而提高了生物利用度。