Composition for improving ovarian function and application thereof

The invention discloses a composition for improving ovarian function. The composition comprises umbilical cord mesenchymal stem cells and umbilical cord blood CGF. The functions of stem cells and CGFare maximized through an ovary multi-site injection administration mode, so that the ovary weight, th...

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Bibliographic Details
Main Authors TANG YILIN, CHEN QIAOLIN
Format Patent
LanguageChinese
English
Published 30.03.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a composition for improving ovarian function. The composition comprises umbilical cord mesenchymal stem cells and umbilical cord blood CGF. The functions of stem cells and CGFare maximized through an ovary multi-site injection administration mode, so that the ovary weight, the follicle number of each stage and the E2 level of an ovarian premature senility model rat are increased, the FSH level and the ovarian granulocyte apoptosis rate are reduced, the Bax protein is remarkably reduced, and the Bcl2 protein is increased. The invention provides a powerful tool for clinically treating the premature ovarian failure and improving the ovarian function. 本发明公开了一种改善卵巢功能的组合物，包括脐带间充质干细胞和脐带血CGF。通过卵巢多位点注入的给药方式，将干细胞和CGF的功能发挥至最大化，使得卵巢早衰模型大鼠卵巢重量、各级卵泡数和E2水平增加，而FSH水平及卵巢颗粒细胞凋亡率下降，Bax蛋白显著降低，Bcl2蛋白升高。本发明为临床治疗卵巢早衰，改善卵巢功能提供了有力工具。
Bibliography:Application Number: CN202011110853