PEGylated metal nano-composite as well as preparation method and application thereof

• Main Authors: CHEN ZEFENG, HE YAN, PAN ZHENXING, ZENG YAOXUN, BIAN WANGQING, YUAN JIONGPENG, LIU XUJIE, WANG YAKUN, CHEN NIPING
• Format: Patent
• Language: Chinese; English
• Published: 26.03.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention discloses a PEGylated metal nano-composite as well as a preparation method and application thereof, and aims to provide the PEGylated metal nano-composite. A two-block polymer of the PEGylated metal nano-composite can adsorb various metal ions to form a corresponding nano-composite, so that the toxicity of free metal ions is reduced; and the internal circulation time can be prolonged, so that the nano-composite can be accumulated at tumor parts better, and the nano-composite has excellent tumor therapy and imaging effects. According to the technical scheme, the PEG diblock polymer and metal ions are subjected to electrostatic adsorption to obtain the PEG modified metal nano-composite. 本发明公开了一种聚乙二醇化金属纳米复合物及其制备方法与应用，旨在提供一种聚乙二醇化金属纳米复合物，其两嵌段聚合物能够对多种金属离子进行吸附，形成对应的纳米复合物，降低了游离金属离子的毒性；并能提高体内循环时间，以利于纳米复合物在肿瘤部位更好地蓄积，使纳米复合物具备优良的肿瘤治疗和成像效果，其技术方案是将聚乙二醇两嵌段聚合物与金属离子进行静电吸附，得到聚乙二醇修饰的金属纳米复合物。