Method for preparing N-isopropylacrylamide based on 3-halogen-N-isopropylpropionamide

• Main Authors: LI XIANSONG, YANG KAI
• Format: Patent
• Language: Chinese; English
• Published: 19.03.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a method for preparing N-isopropylacrylamide based on 3-halogen-N-isopropylpropionamide. The method comprises the following steps of: (1) mixing the 3-halogen-N-isopropylpropionamide with a metal salt of alcohol in a molar ratio of 1-1:3; (2) placing the mixed substance in the step (1) in a vacuum heating environment to react under a vacuum degree ranging from -0.01 to -0.099MPa and a heating temperature of 90DEG C-100DEG C; (3) after the reaction in the step (2) is finished, adding an extraction agent for extraction treatment; (4) filtering and distilling the substanceextracted in the step (3); and (5) adding a recrystallization solvent into the substance treated in the step (4), and carrying out recrystallization treatment to obtain the N-isopropylacrylamide. Themethod has the advantages of low equipment requirements, simple charging sequence, easy control of the temperature of the reaction stage, simple subsequent separation and purification operation, lowimpurity content of the pro