Preparation method and application of tumor acid environment response nano prodrug

• Main Authors: CHEN GANG, ZHENG HUA, LEI MENGHENG, LI DAN, ZHANG MENGYAO
• Format: Patent
• Language: Chinese; English
• Published: 19.03.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention discloses a preparation method and application of a tumor acid environment response nano prodrug. The preparation method of the nano prodrug comprises the following steps: firstly, partially oxidizing glucuronic acid ring of hyaluronic acid with sodium periodate to obtain hyaluronic acid containing an aldehyde group, and connecting the obtained product with doxorubicin and aminoferrocene through imine bonds to obtain a hyaluronic acid nano prodrug, and preparing prodrug nano-particles through an ultrasonic-assisted self-assembly method. The prodrug nanoparticle has good biocompatibility and good in-vitro stability, simultaneously loads two anti-cancer drugs of adriamycin and aminoferrocene through an imine bond, has pH sensitivity, can selectively release a large amount of drugs in a tumor acid environment, realizes combined introduction of chemotherapy and chemokinetics therapy, significantly improves the treatment effect, the toxic and side effects of the medicine on normal tissues and cells a