METHODS OF TREATING CANCER

Therapeutic methods and pharmaceutical compositions for treating cancer including a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis in a human subject are described. In certain embodiments, the invention includes therapeu...

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Bibliographic Details
Main Author ROTHBAUM WAYNE
Format Patent
LanguageChinese
English
Published 16.03.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Therapeutic methods and pharmaceutical compositions for treating cancer including a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis in a human subject are described. In certain embodiments, the invention includes therapeutic methods of treating a MPN using a MDM2 inhibitor of Formula (I) or Formula (II). 描述了用于治疗人类受试者中的癌症的治疗方法和药物组合物，所述癌症包括骨髓增殖性肿瘤(MPN)，包括真性红细胞增多症(PV)、特发性血小板增多症(ET)和原发性骨髓纤维化。在某些实施例中，本发明包括使用式(I)或式(II)的MDM2抑制剂治疗MPN的治疗方法。
Bibliography:Application Number: CN20198043405