Preparation method and application of double-drug combined intelligent antibacterial hydrogel

• Main Authors: CHEN GANG, ZHENG HUA, LEI MENGHENG, LI DAN, ZHANG MENGYAO
• Format: Patent
• Language: Chinese; English
• Published: 12.03.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a preparation method and application of double-drug combined intelligent antibacterial hydrogel. The preparation process of the hydrogel comprises the following steps: oxidizing dextran (Dex) by adopting a sodium periodate oxidation method, breaking part of chains in dextran to form furfural, then reacting primary amino in sulfadiazine with part of aldehyde groups in furfural to generate pH sensitive imine bonds, and reacting and cross-linking residual aldehyde groups in furfural with tobramycin in water, and carrying out self-assembly to form the hydrogel. The hydrogelhas a pH sensitive characteristic, can effectively release drugs in an inflammatory subacid environment, realizes on-demand release of the drugs, avoids excessive use of antibiotics, reduces toxic and side effects of the drugs, simultaneously loads two bactericidal drugs sulfadiazine and tobramycin, kills bacteria through different mechanisms, improves an antibacterial effect, and has an excellent antibacterial effect. 本