Simple and convenient synthesis method of meta-substituted phenol ether and phenol

• Main Authors: ZHANG ZHIHUA, JIANG DAHONG, WANG XU, ZHANG GUIXI, CUI BAOCHEN, LI LEI
• Format: Patent
• Language: Chinese; English
• Published: 09.03.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention relates to the technical field of biological medicines, and provides a preparation method of meta-substituted phenol ether. The method comprises the following steps: taking a derivativeof meta-substituted cyclohexenone as a reaction raw material, reacting under the conditions of an alcohol solvent and an oxidant to obtain corresponding meta-substituted phenol ether; the reaction process is easy to control, the substrate range is wide, and a foundation is laid for providing a simpler and more convenient synthesis method for subsequent preparation of meta-substituted phenol; the invention also provides a simple synthesis method of meta-substituted phenol, and the meta-substituted phenol ether prepared by the method is used as a reaction raw material to solve the problems of need of a noble metal catalyst, high reaction control difficulty and narrow substrate range in the meta-substituted phenol preparation process in the prior art. 本发明涉及生物医药技术领域，提供一种间位取代的酚醚的制备方法。以间位取代的环己烯酮的衍生物为反应原料，在醇溶剂及氧化剂条件下反应得到