Vitamin K2 microcapsule, preparation method thereof and application thereof in preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases

• Main Authors: LIN MURONG, WEI CHUQUAN, WANG XUERUI, WANG WENJI, LIU JINHONG
• Format: Patent
• Language: Chinese; English
• Published: 23.02.2021
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY ASINGLE OTHER SUBCLASS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention belongs to the technical field of vitamin K2, and relates to a vitamin K2 microcapsule, a preparation method thereof and an application of the vitamin K2 microcapsule in preparation of medicines for preventing and treating cardiovascular and cerebrovascular diseases. The vitamin K2 microcapsule contains the following components in parts by weight: 0.001-10 parts of vitamin K2, 5-30 parts of a polyunsaturated fatty acid source, 0.1-10 parts of vitamin E polyethylene glycol succinate, 50-95 parts of a water-phase wall material and 0.01-10 parts of an antioxidant, wherein the polyunsaturated fatty acid source contains an omega-6 source and an omega-3 source, and the antioxidant is a water-phase antioxidant and/or an oil-phase antioxidant. The vitamin K2 microcapsule prepared bythe method provided by the invention has good water solubility and stability and high bioavailability, can significantly improve the prevention and/or treatment effect on cardiovascular and cerebrovascular diseases, and has b