METHOD OF TREATMENT WITH HISTAMINE-3 RECEPTOR INVERSE AGONIST

• Main Authors: NIROGI RAMAKRISHNA, SHINDE ANIL KARBHARI, JAYARAJAN PRADEEP, BENADE VIJAY SIDRAM, DARIPELLI SAIVISHAL, RAVULA JYOTHSNA, JASTI VENKATESWARLU
• Format: Patent
• Language: Chinese; English
• Published: 12.02.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides new methods of treatment for narcolepsy, excessive daytime sleepiness, obstructive sleep apnea, circadian rhythm sleep disorders, sleep and vigilance disorders associated with Parkinson's disease, multiple sclerosis, dementia or attention deficit hyperactivity disorder by administering a therapeutically effect amount of histamine-3 receptor (H3R) inverse agonist, N-[4-(l-Cyclobutylpiperidin-4-yloxy)phenyl]- 2-(morpholin-4-yl)acetamide or a pharmaceutically acceptable salt thereof. The present invention further provides use of the said compounds in the manufactureof medicament intended for the treatment of the disorders described herein. 本发明提供了通过施用治疗有效量的组胺-3受体(H3R)反向激动剂N-[4-(1-环丁基哌啶-4-基氧基)苯基]-2-(吗啉-4-基)乙酰胺或其可药用盐来治疗发作性睡病、日间过度嗜睡、阻塞性睡眠呼吸暂停、昼夜节律性睡眠障碍，与帕金森病、多发性硬化、痴呆或注意缺陷多动障碍相关的睡眠和警觉障碍的新方法。本发明还提供了所述化合物在制备旨在用于治疗本文中所述病症的药物中的用途。