MATERIALS AND METHODS FOR TREATING STRESS-RELATED DISORDERS AND CANCER

• Main Authors: GIASSON BENOIT, GOLDE TODD ELIOT, MOORE BRENDA DAWN, FUTCH HUNTER S
• Format: Patent
• Language: Chinese; English
• Published: 09.02.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed herein are materials and methods for the treatment of stress-related disorders and cancer. The disclosure provides an antibody, or antigen binding fragment thereof, that specifically binds to a region of corticotropin-releasing hormone (CRH). The disclosure also provides methods of treating a disorder associated with HPA axis activation, such as a stress-related disorder or cancer, comprising administering to a subject in need thereof an antibody or antigen binding fragment thereof described herein in an amount effective to treat the disorder. 本文公开了用于治疗应激相关病症和癌症的材料和方法。本公开提供了一种抗体或其抗原结合片段，其与促肾上腺皮质激素释放激素（CRH）的区域特异性结合。本公开还提供了治疗与HPA轴活化相关的如应激相关病症或癌症等病症的方法，所述方法包括向有需要的受试者施用有效治疗所述病症的量的本文所述的抗体或其抗原结合片段。