Preparation method and application of composite reticular film loaded with PLGA/triamcinolone acetonide microspheres

The invention provides a preparation method of a composite reticular film loaded with PLGA/triamcinolone acetonide microspheres. The preparation method comprises the following steps of 1.1, preparingthe PLGA microspheres coated with a triamcinolone acetonide drug by using a solvent emulsification vo...

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Bibliographic Details
Main Authors NI WENKAI, XIAO MINGBING, ZHENG WENJIE, ZHAO XUYING, BIAN SAIYAN
Format Patent
LanguageChinese
English
Published 05.02.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides a preparation method of a composite reticular film loaded with PLGA/triamcinolone acetonide microspheres. The preparation method comprises the following steps of 1.1, preparingthe PLGA microspheres coated with a triamcinolone acetonide drug by using a solvent emulsification volatilization method; and 1.2, dissolving the PLGA microspheres coated with the triamcinolone acetonide drug in 0.2 M of chitosan acetate/collagen/genipin solution, and preparing the PLGA/triamcinolone acetonide microsphere loaded composite reticular film by a freeze-drying method. The composite reticular film provided by the invention is used for preventing esophageal ESD postoperative stenosis. The preparation method comprises the following steps of firstly, wrapping triamcinolone acetonide with PLGA to form microspheres, and loading the microspheres into a genipin cross-linked chitosan/collagen reticular film; and then, detecting an in-vitro long-acting release curve of triamcinolone acetonide in the composite fi
Bibliography:Application Number: CN202011317082