PROTON PUMP INHIBITORS AND METHODS OF USE IN CHEMORADIATION-INDUCED TISSUE INFLAMMATION AND SCARRING

• Main Authors: GHEBRE YOHANNES T, BONNEN MARK D, LUDWIG MICHELL S, JHAVERI PAVAN M
• Format: Patent
• Language: Chinese; English
• Published: 02.02.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Embodiments of the disclosure include methods and compositions related to treatment or prevention of cancer therapy-induced tissue inflammation, dermatitis, and/or scarring. In particular embodimentsone or more proton pump inhibitors are provided to an individual before, during, and/or after receiving anticancer therapy. In some embodiments one or more proton pump inhibitors are provided to an individual before, during, and/or after having a health conditions, allergies, genetic factors and/or exposure to one or more irritants. 本公开的实施方案包括涉及治疗或预防癌症疗法诱发的组织炎症、皮炎和/或瘢痕的方法和组合物。在具体的实施方案中，将一种或多种质子泵抑制剂在接受抗癌疗法之前、期间和/或之后提供给个体。在一些实施方案中，将一种或多种质子泵抑制剂在具有健康状况、变态反应、遗传因素和/或暴露于一种或多种刺激物之前、期间和/或之后提供给个体。