Preparation method and application of gamma-Fe2O3 vortex magnetic nanoring

• Main Authors: GUO YINGKUN, LIU HANRUI, PENG MINGLI, FAN HAIMING, LIU XIAOLI
• Format: Patent
• Language: Chinese; English
• Published: 26.01.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEASURING; MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

The invention belongs to the field of biological cytology, and particularly relates to a preparation method and application of a gamma-Fe2O3 vortex magnetic nanoring. The gamma-Fe2O3 vortex magnetic nanoring is used; stem cells are marked under an alternating magnetic field of the gamma-Fe2O3 vortex magnetic nanoring; the gamma-Fe2O3 vortex magnetic nanoring generates nano heat under the alternating magnetic field to enhance the permeability of cell membranes, so that the endocytosis and marking dose of the cells on a nano material is further increased, and the marking efficiency of the stem cells is improved; the residence time of an iron oxide nano material in the cells is prolonged; and long-time tracing of the stem cells is realized. 本发明属于生物细胞学领域，具体涉及一种γ-Fe2O3涡旋磁纳米环的制备方法以及应用。本发明使用γ-Fe2O3涡旋磁纳米环；利用其交变磁场下对干细胞进行标记；γ-Fe2O3涡旋磁纳米环在交变磁场下产生纳米热而增强细胞膜的渗透性，从而进一步增加细胞对纳米材料内吞和标记量剂量，不仅提高了干细胞的标记效率；增长氧化铁纳米材料在细胞内的滞留时间；实现了干细胞的长时间示踪。