Compound oral solution and preparation method thereof

• Main Authors: ZHONG XIAOLI, LIU YA, QU YUNZHI, HE DEZHONG, DU HONGRU, ZHONG MAOTUAN
• Format: Patent
• Language: Chinese; English
• Published: 26.01.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a compound oral solution and a preparation method thereof. The preparation method comprises the following steps of: S1, dissolving a cosolvent in a solvent to prepare a solution, and then dividing the solution into two parts, namely a solution a and a solution b; S2, adding guaiacol glyceryl ether into the solution a, and fully stirring and dissolving to obtain a solution c; adding acetaminophen into the solution b, and fully stirring and dissolving to obtain a solution d; S3, putting a stabilizer, a flavoring agent, a thickening agent, a PH regulator and a complexing agent into a liquid preparation tank, adding a solvent for dissolving, uniformly mixing, and then adding phenylephrine hydrochloride and dextromethorphan hydrobromide to obtain a solution e; and S4, uniformly mixing the solution c and the solution d obtained in the step S2 with the solution e obtained in the step S3 to obtain the compound oral solution. The preparation method disclosed by the invention is carried out at n