Coiled coil immunoglobulin fusion proteins and compositions thereof

• Main Authors: WANG YING, LIU YAN, SCHULTZ PETER G, ZHANG YONG, WANG FENG
• Format: Patent
• Language: Chinese; English
• Published: 15.01.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; SPIRITS; VINEGAR; WINE

Disclosed herein are immunoglobulin fusion proteins comprising a first antibody region, a first therapeutic agent, and a first connecting peptide; wherein the first therapeutic agent is attached to the first antibody region by the connecting peptide; and wherein the connecting peptide does not comprise a region having beta strand secondary structure. The connecting peptide may comprise an extenderpeptide. The extender peptide may have an alpha helical secondary structure. The connecting peptide may comprise a linker peptide. The linker peptide may not comprise any secondary structure. Also disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject. 本文公开了包含第一抗体区、第一治疗剂和第一连结肽的免疫球蛋白融合蛋白；其中第一治疗剂通过该连结肽附接至第一抗体区；并且其中该连结肽不包含具有β链二级结构的区域。该连结肽可包含延伸物肽。该延伸物肽可具有α螺旋二级结构。该连结肽可包含连接体肽。该连接体肽可不包含任何二级结构。本文还公开了包含该免疫球蛋白融合蛋白的组合物和使用该免疫球蛋白融合蛋白治疗或预防受试者中的疾病或病状的方法。