Purification method of oxaliplatin

• Main Authors: LI ZHONGJING, WANG YABAI, SHEN GUANGBIN
• Format: Patent
• Language: Chinese; English
• Published: 12.01.2021
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a purification method of oxaliplatin. The final silver removal operation of oxaliplatin purification is changed into an electrolytic tank method from an original chemical method, so other halogenating reagents can be avoided, and silver ion removal effect is superior compared with other chemical removal methods. The method is simple in reaction conditions, simple, convenient and efficient to operate, safe to implement, more friendly to environment and suitable for industrial production, and meets the requirements of green chemistry and atomic economy. 本发明公开了一种奥沙利铂的纯化方法。本发明将纯化奥沙利铂的最后除银操作由原来的化学方法改为电解池方法，可避免使用其它卤化试剂，且去除银离子的效果优于其它化学去除法。本发明反应条件简单，操作简便高效，安全环保，对环境更加友好，适合产业化生产，符合绿色化学与原子经济学的要求。