SYSTEM AND METHOD FOR CONTROLLING FLUID FLOW WITHIN A CHROMATOGRAPHY SYSTEM

• Main Authors: SHREVE JOSHUA A, FOGWILL MICHAEL O, MCDONALD THOMAS S
• Format: Patent
• Language: Chinese; English
• Published: 08.01.2021
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; SEPARATION; TESTING; TRANSPORTING

The present disclosure relates to methodologies, systems, apparatus, and kits for controlling fluid flow within a chromatography system. A makeup pump is configured to pump a makeup fluid into the chromatography system downstream of the column. A first restrictor is located upstream of a detector and downstream of both the makeup pump and the column. Decreasing an output volume of the makeup pumpcan direct an output from the column through the first restrictor to the detector. Increasing an output volume of the makeup pump can direct the output from the column to a second restrictor located downstream of the makeup pump and the column and in parallel with the first restrictor and the detector. 本公开涉及用于控制色谱系统内的流体流的方法、系统、装置和套件。补给泵被配置为将补给流体在柱的下游泵送到所述色谱系统中。第一限流器位于检测器的上游以及所述补给泵和所述柱两者的下游。减小所述补给泵的输出体积可将来自所述柱的输出引导通过所述第一限流器到达所述检测器。增加所述补给泵的输出体积可将来自所述柱的所述输出引导到位于所述补给泵和所述柱的下游并且与所述第一限流器和所述检测器平行的第二限流器。