Modified natural killer cells and uses thereof

• Main Authors: CAMPANA DARIO, SHOOK DAVID, IMAMURA MASARU
• Format: Patent
• Language: Chinese; English
• Published: 05.01.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The inventionfurther provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survivalof NK cells. 本申请涉及经修饰的自然杀伤细胞及其用途。本申请在某些方面提供了表达白介素-15(IL-15)的全部或功能部分的自然杀伤(NK)细胞，以及用于产生这样的细胞的方法。本申请还提供了使用表达白介素-15(IL-15)的全部或功能部分的自然杀伤(NK)细胞来治疗对象中的癌症或者增强NK细胞的扩增和/或存活的方法。