Method for evaluating risk of Down's syndrome based on m6A methylation modification of NRIP1 mRNA and application of method

• Main Authors: SHI WEILI, YANG FAN
• Format: Patent
• Language: Chinese; English
• Published: 29.12.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention discloses a method for evaluating the risk of Down's syndrome based on m6A methylation modification of NRIP1 mRNA and application of the method. The method comprises the following steps:measuring the m6A methylation modification level of NRIP1 mRNA in a tissue sample of a subject to obtain a measured value; comparing the measured value with a control value; and judging the relationship between the differentiated modification of m6A methylation and the risk of Down's syndrome. The method can be effectively used for screening Down's syndrome. 本发明公开一种基于NRIP1 mRNA的m6A甲基化修饰评估唐氏综合征风险的方法及其应用。本发明的方法包括：测量受试者组织样品中的NRIP1 mRNA的m6A甲基化修饰水平得到测量值的步骤；将所述测量值与对照值比较的步骤；判断m6A甲基化的差异化修饰与患唐氏综合征的风险的高低的关系。本发明可有效地用于唐氏综合征的筛查。