Inhibitors of lysine specific demethylase-1

• Main Authors: STAFFORD JEFFREY ALAN, KANOUNI TOUFIKE, VEAL JAMES MARVIN, CHEN YOUNG K
• Format: Patent
• Language: Chinese; English
• Published: 25.12.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to inhibitors of lysine specific demethylase-1. The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like. 本申请涉及赖氨酸特异性脱甲基酶-1的抑制剂。本申请总体上涉及用于治疗癌症和肿瘤疾病的组合物和方法。本文提供了被取代的杂环衍生物化合物和包含所述化合物的药物组合物。主题化合物和组合物对于抑制赖氨酸特异性脱甲基酶-1是有用的。此外，主题化合物和组合物对于癌症，例如前列腺癌、乳腺癌、膀胱癌、肺癌和/或黑色素瘤及类似癌症的治疗是有用的。