THERAPEUTIC CELL SYSTEMS AND METHODS FOR TREATING CANCER AND INFECTIOUS DISEASES

• Main Authors: WICKHAM THOMAS J, ELLOUL SIVAN
• Format: Patent
• Language: Chinese; English
• Published: 18.12.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present disclosure relates to erythroid cells that have been engineered to include, e.g., at the surface of the cell, one or more exogenous stimulatory polypeptides, wherein the exogenous stimulatory polypeptides presented are sufficient to stimulate an immune killer cell. The engineered enucleated cells of the present disclosure are useful in methods of activating NK cells and/or CD8+T-cellsin a subject in need thereof, such as subjects having cancer or an infectious disease, and in particular cancers or infectious diseases characterized by downregulation of MHC Class I presentation. 本公开涉及红系细胞，其已经被工程化改造成例如在细胞表面处包含一种或多种外源刺激性多肽，其中所呈现的外源刺激性多肽足以刺激免疫杀伤细胞。本公开的工程化去核细胞可用于在有此需要的受试者，如患有癌症或传染病，特别是以MHC I类呈递下调为特征的癌症或传染病的受试者中活化NK细胞和/或CD8+T细胞的方法。