C3-BINDING AGENTS AND METHODS OF USE THEREOF

• Main Authors: ZHAI WENWU, LIU ZHONGHAO, YIN YIYUAN, HIGBEE JARED MARTIN, TANG JIE, DUEY DANA YEN MEI, WANG YAN
• Format: Patent
• Language: Chinese; English
• Published: 18.12.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same. 本公开提供了特异性结合补体组分C3(包括人C3)的结合剂，诸如抗体(包括单链可变片段)；包含所述结合剂的组合物，及其使用方法。本公开还提供了编码所述结合剂的相关多核苷酸和载体以及包含所述多核苷酸和载体的细胞。