Preparation method of L-carnitine catechuate

The invention discloses a preparation method of L-carnitine catechuate, which comprises the following steps: 1. adding a solvent into a reactor, and cooling to 5-15 DEG C; 2, adding an antioxidant under the protection of nitrogen; 3, L-carnitine and catechuic acid being sequentially fed into the rea...

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Bibliographic Details
Main Authors HE LIANSHUN, LI BINSHUI
Format Patent
LanguageChinese
English
Published 15.12.2020
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a preparation method of L-carnitine catechuate, which comprises the following steps: 1. adding a solvent into a reactor, and cooling to 5-15 DEG C; 2, adding an antioxidant under the protection of nitrogen; 3, L-carnitine and catechuic acid being sequentially fed into the reactor, the mass ratio of the L-carnitine to the antioxidant being 100: 1, the molar ratio of the L-carnitine to the catechuic acid being 1: 0.51: 2.0, meanwhile, the temperature is increased to 30-75 DEG C, and stirring till reactants are completely dissolved; 4, closing the nitrogen, and evaporatingthe solvent under the pressure of which the vacuum degree is less than 0.095 mpa until the solution becomes turbid; 5, starting nitrogen protection, stirring, cooling to room temperature, continuously cooling to -5-0 DEG C, and keeping the temperature for 2 hours; and 6, filtering, washing and drying to obtain a finished product. The preparation process is simple in steps, few in impurities, stable in product quality and
Bibliography:Application Number: CN202010986694