Regulation effect of hydrogen-rich water on liver cholesterol metabolism related genes

• Main Author: RUAN GUOHONG
• Format: Patent
• Language: Chinese; English
• Published: 15.12.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a regulation effect of hydrogen-rich water on liver cholesterol metabolism related genes. According to the regulation effect, a hypercholesterolemia mouse model is established,meanwhile, hydrogen-rich water with different concentrations of hydrogen molecules is adopted for intervention, biomarkers participating in cholesterol metabolism in the liver are quantitatively analyzed, and the influence and the possible mechanism of the hydrogen-rich water on the liver cholesterol metabolism of the hypercholesterolemia mouse are researched. Experiments show that the hydrogen-rich water reduces the serum LDL-C level, promotes the conversion of cholesterol into bile acid and reduces the cholesterol level by up-regulating the expression of SREBP2, LDLR, LXR and CYP7A1, so that the hydrogen-rich water can be used for preparing medicines for reducing cholesterol. 本发明公开了富氢水对肝脏胆固醇代谢相关基因的调节作用，本发明通过建立高胆固醇血症小鼠模型，同时采用不同浓度氢分子的富氢水进行干预，定量分析肝脏中参与胆固醇代谢的生物标志物，研究富氢水对高胆固醇血症小鼠肝脏胆固醇代谢的影响及可能机制。通过实验发现，富氢水通过上调SREBP2、