NLRP3 MODULATORS

The present invention provides compounds of Formula (I): wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatmentof proliferative disorders, such as cancer in a subject (e.g., a human). 本发明提供了式(I)化合物：其中所有变量均如本文所定义...

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Bibliographic Details
Main Authors SEITZ STEVEN P, ROUSH WILLIAM R, GAVAI ASHVINIKUMAR V, GHOSH SHOMIR, MARKWALDER JAY A, SIVAPRAKASAM PRASANNA, DONNELL ANDREW F, ZHANG YONG
Format Patent
LanguageChinese
English
Published 11.12.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula (I): wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatmentof proliferative disorders, such as cancer in a subject (e.g., a human). 本发明提供了式(I)化合物：其中所有变量均如本文所定义。这些化合物是NLRP3调节剂，其可用作用于治疗个体(例如人)的增殖性障碍(例如癌症)的药物。
Bibliography:Application Number: CN201980027881