Application of gene therapy product for telomeres and mammalian generalized promoters

• Main Author: LIU YUWEN
• Format: Patent
• Language: Chinese; English
• Published: 11.12.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

In human cells, every time the cells are divided, telomeres at top ends of chromosomes are shortened once, and when the telomeres cannot be shortened any longer, the cells cannot be further divided. At the moment, the cells open an apoptosis signal path. Regarded as the "life clock", the telomeres have important functions of protecting the stability of the chromosomes and recognizing the origin during cell renewing and division; the length of the telomeres achieves the functions of promoters and silencers; the telomeres act on regulation of expression of downstream proteins of the chromosomes;the expression of the proteins have various correlations with ageing; telomere prolonging is very important for healthy ageing reversing; According to the invention, an adenovirus gene therapy vectoris used, and a gene replication defect is utilized to control telomerase activity, thus avoiding the carcinogenic risk. Through the adenovirus gene therapy vector, human cell telomeres are prolonged,the number of division tim