抗ANGPTL3抗体及其用途

本发明提供了一种抗体或抗原结合片段，其与血管生成素样蛋白3(ANGPTL3)结合，并抑制或干扰其至少一种活性。该抗ANGPTL3抗体可用于治疗与ANGPTL3相关的疾病或失调，如高脂血症、高脂蛋白血症和血脂异常，包括高甘油三酯血症、高胆固醇血症等。此外，该抗ANGPTL3抗体可以给需要预防或治疗疾病或失调的受试者施用，这类疾病或失调包括心血管疾病，如动脉粥样硬化和冠状动脉疾病、非酒精性脂肪性肝炎(NASH)、糖尿病、肥胖症等。 The invention provides an antibody or antigen binding fragment. The antibody or anti...

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Bibliographic Details
Format Patent
LanguageChinese
Published 19.07.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:本发明提供了一种抗体或抗原结合片段，其与血管生成素样蛋白3(ANGPTL3)结合，并抑制或干扰其至少一种活性。该抗ANGPTL3抗体可用于治疗与ANGPTL3相关的疾病或失调，如高脂血症、高脂蛋白血症和血脂异常，包括高甘油三酯血症、高胆固醇血症等。此外，该抗ANGPTL3抗体可以给需要预防或治疗疾病或失调的受试者施用，这类疾病或失调包括心血管疾病，如动脉粥样硬化和冠状动脉疾病、非酒精性脂肪性肝炎(NASH)、糖尿病、肥胖症等。 The invention provides an antibody or antigen binding fragment. The antibody or antigen binding fragment binds to angiopoietin-like protein 3 (ANGPTL3), and inhibits or interferes at least one activity thereof. The anti-ANGPTL3 antibody can be used for treating diseases or disorders related to ANGPTL3, such as hyperlipidaemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia,hypercholesterolemia and the like. In addition, the anti-ANGPTL3 antibody can be used for a subject in need of prevention or treatment of diseases or disorders, and the diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases, non-alcoholic steatohepatitis (NASH), diabetes, obesity, and the like.
Bibliography:Application Number: CN202010446335