Bovine serum albumin modified protoporphyrin/trimanganese tetroxide /carbon oxynitride nano composite material as well as preparation and application thereof

• Main Authors: TIAN YA, LIU YEPING, YANG SHIPING, WU HUIXIA
• Format: Patent
• Language: Chinese; English
• Published: 11.12.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention relates to a bovine serum albumin modified protoporphyrin/trimanganese tetroxide/carbon oxynitride nano composite material as well as preparation and application thereof. The preparationmethod comprises the following steps: (1) preparing a uniformly dispersed carbon oxynitride nanosheet aqueous solution; (2) sequentially adding manganese acetate tetrahydrate and triethylamine into the carbon oxynitride nanosheet aqueous solution obtained in the step (1), performing continuous stirring, and preparing a trimanganese tetroxide-loaded carbon oxynitride nanomaterial through an in-situ growth method; and (3) loading protoporphyrin to the surface of the trimanganese tetroxide-loaded carbon oxynitride nanomaterial obtained in the step (2) by stirring, and adding bovine serum albuminfor modification. The material prepared by the method disclosed by the invention can be applied to magnetic resonance imaging and tumor sonodynamic therapy. Compared with the prior art, the bovine serum albumin modified proto