Method for preparing piperacillin sodium and tazobactam sodium freeze-dried powder by microreactor

• Main Authors: QIN CHUNXIA, YANG QINGKUN, ZHONG XINGLI, HOU CHUANSHAN, LI HONGYUN, ZHOU XIANFENG, LI ZHUOHUA
• Format: Patent
• Language: Chinese; English
• Published: 11.12.2020
• Subjects: BABY COMFORTERS; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR RECEIVING SPITTLE; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a method for preparing piperacillin sodium and tazobactam sodium freeze-dried powder by a microreactor. According to the method, an inorganic alkali solution and a piperacillinand tazobactam suspension solution enter a mixer to be mixed together by controlling a certain flow rate and enter a microreactor to react, the mixture is taken out of the microreactor after the reaction is completed, and piperacillin sodium and tazobactam sodium freeze-dried powder is obtained after filtration, sterilization and freeze-drying. According to the method, rapid reaction of the microreactor is utilized, so that degradation impurity increase caused by too high local concentration of alkali liquor is avoided, nitrogen does not need to be introduced in the reaction process, carbon dioxide generated in the reaction process does not need to be removed by vacuumizing and is directly discharged into the air; and due to short residence time in a micro-reaction unit and rapid reaction, the spraying phenomenon