Method for synthesizing 1,5-diketone compound by oxidizing diketene in air

• Main Authors: XIA AIBAO, FENG KAIXIANG, HUANG LISHA
• Format: Patent
• Language: Chinese; English
• Published: 08.12.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

According to the method, a chiral primary amine catalyst and an iodine catalyst are adopted, and a simple route for synthesizing the 1,5-diketone compound is explored through a 1,6-addition reaction,C-C bond breakage and an epoxidation reaction under mild conditions. The invention aims to prepare 1,5-diketone compounds without using toxic transition metals and excessive stoichiometric oxidants, provides a method for synthesizing 1,5-diketone compounds by oxidizing diketene in air and application, and develops oxidative cracking of iodine-catalyzed C-C delta bonds, the reaction is based on a 1,6-addition reaction, and the method is suitable for industrial production of 1,5-diketone compounds. Simple air oxygen is used as an oxygen source to carry out a bifunctionalization reaction on dienone. 本发明采用手性伯胺催化剂和碘催化剂，在温和的条件通过1,6-加成反应、C-C键断裂和环氧化反应，探索一条简易的合成1,5-二酮类化合物的路线。本发明的目的在于制备1,5-二酮化合物避免使用有毒的过渡金属和过量的化学计量的氧化剂，提供一种空气氧化二烯酮合成1,5-二酮类化合物的方法与应用，我们开发了一种碘催化的C-Cδ键的氧化裂解，该反应基于1,6-加成反应，以简单的空气氧作为氧源对二烯酮进行双官能化反应。