In situ methods of inducing of immune response

The present disclosure relates to intraductal methods and compositions for inducing immune response in subjects having breast cancer. The intraductally administered compositions comprise one or more bioactive agents capable of inducing in situ maturation of antigen presenting cells and migration of...

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Bibliographic Details
Main Author QUAY STEVEN C
Format Patent
LanguageChinese
English
Published 04.12.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure relates to intraductal methods and compositions for inducing immune response in subjects having breast cancer. The intraductally administered compositions comprise one or more bioactive agents capable of inducing in situ maturation of antigen presenting cells and migration of mature antigen presenting cells to lymph nodes. The intraductal methods and compositions induce theactivation of effector immune cells, and augment tumor cell death. 本公开涉及用于在患有乳腺癌的受试者中诱导免疫应答的导管内方法和组合物。导管内施用的所述组合物包含能够诱导抗原呈递细胞原位成熟和成熟抗原呈递细胞向淋巴结迁移的一种或多种生物活性剂。所述导管内方法和组合物诱导效应免疫细胞的活化，并增加肿瘤细胞死亡。
Bibliography:Application Number: CN201980028970