Tablet formulation for CGRP-active compounds

The present invention relates to a composition comprising an extrudate or solid solution of a compound of formula I, or a salt thereof (API), in a water-soluble polymer matrix, where Ra is independently H or F, the composition further comprising a disintegration system that allows tablets prepared t...

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Main Authors IKEDA CRAIG B, FLANAGAN JR. FRANCIS J, XI HANMI, NOFSINGER REBECCA, EICKHOFF W. MARK, LUPTON LISA, BROWN CHAD D, PATEL PARESH B, MAROTA MELANIE, XU WEI, JOHNSON MARY ANN, ALLAIN LEONARDO RESENDE
Format Patent
LanguageChinese
English
Published 04.12.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a composition comprising an extrudate or solid solution of a compound of formula I, or a salt thereof (API), in a water-soluble polymer matrix, where Ra is independently H or F, the composition further comprising a disintegration system that allows tablets prepared therefrom to disintegrate rapidly in an environment in which API is to be released. 本发明涉及一种包含式I化合物或其盐(API)在水溶性聚合物基质中的挤出物或固体溶液的组合物，其中"Ra"独立地是-H或-F，所述组合物进一步包含崩解系统，其允许由其制备的片剂在待释放API的环境中快速崩解。
Bibliography:Application Number: CN202010812438